potential-relationships-between-apelin-and-metabolic-associated-indices-in-transition-dairy-cows-–-springer

Potential relationships between apelin and metabolic-associated indices in transition dairy cows – Springer

Abstract

Metabolic disorders pose significant challenges in transition dairy cows. Numerous parameters have been investigated in this context, and apelin has recently emerged as a potential metabolic indicator. Accordingly, this study aimed to assess the associations between this hormone and other metabolic parameters. Twenty-two adult Holstein-Friesian dairy cows, 21 days before their expected calving date, were selected for blood sampling and serum separation at four time points: 21 and 10 days before calving and 10 and 21 days after parturition. Serum concentrations of apelin, leptin, insulin, cortisol, T3, T4, non-esterified fatty acids, glucose, total protein, albumin, globulin, aspartate aminotransferase, alanine transaminase, triglycerides, cholesterol, high, low and very low-density lipoproteins, total, direct and indirect bilirubin were measured in these samples. Surrogate indices for insulin resistance, body condition score, and milk production were also evaluated. Throughout the transition period, a significant increase in apelin levels was observed. Various models were employed to identify associations between apelin and the studied metabolic parameters. Notably, significant correlations between apelin and Leptin, Insulin, Cortisol, T3, T4, NEFA, Cholesterol, LDL, VLDL, Total Protein, Albumin, Globulin, Total Bilirubin, Direct Bilirubin and Indirect Bilirubin were observed, with some being immediate while others developed over time. These findings indicate a mutual influence between apelin and specific metabolic indices. Changes in any component of the metabolic profile at one stage can lead to alterations in apelin levels in subsequent stages. The correlations uncovered between apelin and other components of the metabolic profile in transitioning dairy cows offer valuable insights, contributing to a better understanding of the potential effects of apelin on the studied indicators and vice versa.

Access this article

Log in via an institution

Subscribe and save

  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime

Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Data availability

Data are available.

References

Download references

Funding

Shiraz University.

Author information

Authors and Affiliations

  1. Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

    Amir Salimi Kenari, Aliasghar Chalmeh, Mehrdad Pourjafar, Mohammad Ali Mohtashamifar & Armin Amirian

  2. Veterinarian of Iran Dairy Industries Co.; Pegah Fars, Shiraz, Iran

    Arash Khedri

Contributions

A.S.K.: Investigation, Project administration, Writing – review & editing. A.C.: Conceptualization, Methodology, Formal analysis, Investigation, Resources, Data curation, Writing original draft, Writing – review & editing, Supervision, Project administration. M.P.: Validation, Resources, Writing – review & editing, Supervision, Project administration. M.A.M.: Investigation, Project administration, Writing – review & editing. A.A.: Software, Formal analysis, Data curation, Writing – review & editing, Project administration. A.K.: Investigation, Writing – review & editing.

Corresponding author

Correspondence to Aliasghar Chalmeh.

Ethics declarations

Conflict of interest

There is no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Salimi Kenari, A., Chalmeh, A., Pourjafar, M. et al. Potential relationships between apelin and metabolic-associated indices in transition dairy cows. Trop Anim Health Prod 56, 209 (2024). https://doi.org/10.1007/s11250-024-04043-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11250-024-04043-6

Keywords