Survey on Interaction Between Nutrient Status and Selected Polymorphisms in Association with Weight Loss of Patients … – Springer

Background

There is little information about the effect of single nucleotide polymorphisms (SNP) and nutritional status and weight loss after bariatric surgery. This study investigated the interactive effect of eight obesity-related SNPs and nutritional status on weight loss after Roux-en-Y gastric bypass (RYGB).

Method

This is a case–control study. After 1-year follow-up, the patients who underwent RYGB were dividing into two groups. The case group consisted of patients who lost more than 50% of their excess body weight (EBW%) 1 year after the surgery. The control group included patients who lost < 50% of EBW at same time frame. Then, the relationship between eight SNPs related to UCP2, FTO, LEPR, GHRL, and NPY genes with weight loss were checked.

Results

In this study, 160 patients were recruited. The median of age for case and control group were 43 and 42 respectively. The presence of mutant variant NPYrs16147 had a significant relationship in terms of weight loss between the two groups (P > 0.05). In dominant model, two SNPs, UCP2 rs659366 and UCP2 rs660339, showed protective effect of the vitamin D deficiency.

Conclusion

In conclusion, the presence mutant variant of NPYrs16147 is directly related to the incidence of weight loss greater than 50% of EBW. However, it is apparent individual behavioral, dietary, and other factors may have more influence on weight loss among patients underwent RYGB.

Graphical Abstract

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Authors and Affiliations

1. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran

   Sara Cheraghi, Bahar Moghimian & Azadeh Mottaghi

2. Department of Endocrinology and Metabolism, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

   Golmehr Taheri

3. Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran

   Saeed Safari

4. Heart Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

   Hooman Bakhshandeh

5. Research Center for Prevention of Cardiovascular Diseases, Institute of Endocrinology Metabolism, Iran University of Medical Sciences, Endocrinology & Metabolism, Tehran, Iran

   Mojtaba Malek & Azadeh Mottaghi

Contributions

Conception and design: AM, MM, SS. Laboratory and experimental procedures: SC: data collection: GT, CH, SS, MM. Analysis and interpretation: HB. Writing the article and critical revision: GT, AM. Supervision: AM. Final approval of the article: all authors.

Corresponding author

Correspondence to Azadeh Mottaghi.

Ethics Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The protocol of the current study was approved.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Conflict of Interest

The authors declare no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Key Points

• The presence of mutant NPYrs16147 has protective effect on treatment failure.

• The presence of mutant variants of GHRL rs696217, LEPR rs1137101, FTO rs9939609, rs1421085, NPY rs5574, UCP2 rs659366, and UCP2rs660339 has no association with weight loss after RYGB surgery.

• The interaction between nutritional status and presence of selected SNPs has no effect on weight loss after surgery.

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